Synergistic Effects of C-peptide and Insulin on Low O2-induced ATP
نویسندگان
چکیده
3 Jennifer P. Richards, Alan H. Stephenson, Mary L. Ellsworth 4 and Randy S. Sprague 5 Department of Pharmacological and Physiological Science 6 Saint Louis University 7 St. Louis, MO 63104 8 9 Author for correspondence: 10 Jennifer P. Richards 11 Saint Louis University 12 Department of Pharmacological & Physiological Science 13 School of Medicine 14 1402 South Grand Blvd 15 St. Louis, MO 63104 16 Email: [email protected] 17 18 19 Running title: C-peptide and insulin modulate ATP release from human RBCs 20 21 22 23 24 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (October 2, 2013). doi:10.1152/ajpregu.00341.2013
منابع مشابه
Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes.
Erythrocytes participate in the matching of oxygen (O2) delivery with local need in skeletal muscle via the release of O2 and the vasodilator, ATP. It was reported that a concentration of insulin found in humans with insulin resistance inhibits low O2-induced ATP release. However, in vivo, insulin is coreleased with connecting peptide (C-peptide) at equimolar concentrations, but because of the ...
متن کاملLow O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin.
ATP release from erythrocytes in response to reduced oxygen (O2) tension stimulates local vasodilation, enabling these cells to direct perfusion to areas in skeletal muscle in need of O2. Erythrocytes of humans with type 2 diabetes do not release ATP in response to low O2. Both C-peptide and insulin individually inhibit low O2-induced ATP release from healthy human erythrocytes, yet when coadmi...
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The circulating erythrocyte, by virtue of the regulated release of ATP in response to reduced oxygen (O2) tension, plays a key role in maintaining appropriate perfusion distribution to meet tissue needs. Erythrocytes from individuals with Type 2 diabetes (DM2) fail to release ATP in response to this stimulus. However, the administration of C-peptide and insulin at a 1:1 ratio was shown to resto...
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